AlphaCore Pharma Starts Clinical Trial Of New Heart Drug

ANN ARBOR — The biopharmaceutical company AlphaCore Pharma Friday announced it had started a Phase 1 study of its drug candidate, ACP-501, for the treatment of high-risk atherosclerosis and serious lipid metabolism disorders.

The study is designed to assess the safety, tolerability, pharmacokinetics and lipid effects of ACP-501.

The trial will be conducted by the National Institutes of Health and Robert D. Shamburek, M.D., will serve as the principal investigator of the study.

Bruce Auerbach, president of AlphaCore Pharma, said that ACP-501 represents a promising new approach in the fight against atherosclerotic cardiovascular disease and has demonstrated preclinical efficacy in promoting HDL maturation and cholesterol flux, natural cardioprotective mechanisms by which excess lipids are removed from peripheral tissues.

The program has an eventual goal to reduce the risk of cardiovascular events in patients presenting with acute coronary syndromes.

ACP-501 is recombinant human lecithin, cholesterol acyltransferase (or rhLCAT), an enzyme required for cholesterol metabolism. Additionally, ACP-501 is being developed to treat familial LCAT deficiency (an orphan designated enzyme replacement therapy) and other diseases where LCAT activity is low.

More at www.alphacorepharma.com.

Comments

Leave a Reply

Fill in your details below or click an icon to log in:

Twitter picture

You are commenting using your Twitter account. Log Out / Change )

Facebook photo

You are commenting using your Facebook account. Log Out / Change )

Google+ photo

You are commenting using your Google+ account. Log Out / Change )

Connecting to %s

More From CBS Detroit

Best 4th Of July Concerts In Metro DetroitStaying home this weekend? Celebrate the 4th of July by rocking out at one of these shows.
Hump Day Drinks: 8 Cheery Cocktail RecipesNow that you've made it through half the work week, it's time to celebrate!

Watch & Listen