INDIANAPOLIS (AP) – The family of a southern Michigan woman said Thursday they believe she died of fungal meningitis after receiving two injections of a tainted back pain medication at a northern Indiana clinic.

Pauline Burema, 89, of Cassopolis, Mich., died Wednesday at a daughter’s home in Bristol, Ind., said the woman’s granddaughter, Lisa Ann Durbin.

The family was awaiting autopsy results to confirm the cause of death, Durbin said. However, doctors told the family they think Burema had contracted fungal meningitis from shots she received Aug. 22 and Sept. 8 at OSMC Outpatient Surgery Center in Elkhart.

The Centers for Disease Control and Prevention confirmed an Indiana fungal meningitis death Thursday, and Angela Minicuci, a spokeswoman at the Michigan Department of Community Health (MDCH), said a Cass County, Mich., resident died of fungal meningitis after being treated for back pain in Indiana. Cassopolis is in Cass County.

Burema was found unconscious Oct. 3 in her home about 15 miles north of Elkhart, Durbin said. She had seen her doctor just two days earlier.

“She was in perfect health. She was getting ready to go to New Mexico for the balloon festival,” Durbin, of Decatur, Mich., said in a telephone interview.

The family initially believed Burema suffered a stroke, and she was admitted to an Elkhart County hospital, Durbin said. She regained consciousness, but her condition worsened, and Burema spent her final days at her daughter’s Bristol home.

The family was “pretty upset” when doctors said she contracted meningitis from the steroids she took for recurring back pain, Durbin said.

“It’s kind of a devastating way to pass away. You could tell she was in a lot of pain,” Durbin said. She said her grandmother was being treated with morphine, other painkillers and several different antibiotics. Burema also had a “growing” black fungus inside her mouth before she died, Durbin said.

The family decided to donate Burema’s body for research, Durbin said.

“What our family is hoping is that they can find a cure to maybe help out all the other patients so that not everybody has to die,” she said.

The tainted steroid originated at the New England Compounding Center, a specialty pharmacy in Framingham, Mass.

Don Hammond, chief executive officer of the Elkhart clinic, said 400 patients there received injections from three lots of the tainted medicine, and all have been notified of the threat of contracting meningitis.

The CDC said the meningitis outbreak has reached 170 cases and 14 deaths in 11 states. As of October 10, the MDCH say 29 cases and three deaths have been reported in the state.

Four Michigan facilities received shipments of the contaminated steroids:

  • Michigan Neurosurgical Institutes in Grand Blanc
  • Michigan Pain Specialists in Brighton
  • Neuromuscular and Rehabilitation in Traverse City
  • Southeast Michigan Surgical Hospital in Warren

Fungal meningitis is not transmitted person-to-person. Infected patients have presented approximately one to four weeks following their injection with a variety of symptoms including fever, new or worsening headache, nausea, and other symptoms consistent with a stroke. Some of these patients’ symptoms were very mild in nature.

Any individual who received an epidural steroid injection or steroid injection into a joint at one of the four Michigan facilities and is experiencing symptoms consistent with fungal meningitis or a stroke should immediately contact their physician or seek medical attention.

Patients who have received a steroid injection on or after May 21 and are experiencing symptoms – such as a new or worsening headache, fever, neck stiffness or pain, redness or swelling at the injection site – should immediately contact their physician to receive further evaluation, the department said.

Additional information about this investigation can be found at

TM and © Copyright 2012 CBS Radio Inc. and its relevant subsidiaries. CBS RADIO and EYE Logo TM and Copyright 2012 CBS Broadcasting Inc. Used under license. All Rights Reserved. This material may not be published, broadcast, rewritten or redistributed. The Associated Press contributed to this report.


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