Nyquist had a pair of power-play goals, and Datsyuk and Tomas Tatar also scored in a four-goal first period to help the Red Wings win their third straight at Joe Louis Arena.
The Red Wings opened the scoring midway through the second period following a Washington turnover.
Gordie Howe is said to be out of the hospital and recovering after suffering a stroke.
Multiple reports are saying hockey legend Gordie Howe suffered a serious stroke Sunday in Texas.
Pavel Datsyuk and Riley Sheahan scored for Detroit, which outshot the Flyers 37-17.
Zetterburg streaked down the right side and sent Niklas Kronwall’s centering pass over Jonathan Bernier’s shoulder.
Johan Franzen scored twice and Henrik Zetterberg had four assists to lead the Detroit Red Wings to a 4-1 victory over the Toronto Maple Leafs.
On the winning goal, Getzlaf skated away from Red Wings defenseman Niklas Kronwall in the corner, after what looked to be a penalty, and backhanded a shot past goalie Jimmy Howard.
NHL Commissioner Gary Bettman is fully comfortable with being the dean of those in charge of major North American sports.
The 28-year-old Porter — a Detroit native — has 29 goals and 26 assists in 206 NHL games with Phoenix, Columbus and Buffalo.