Illinois police contacted authorities in Oakland County after stopping the couple for driving the wrong way on I-294.
The car had traveled in the wrong direction on I-275 for about two miles before the collision, police said.
As troopers were making their way to the area, police started receiving more calls that a car had struck another vehicle head-on at westbound I-696 and Coolidge Highway.
Rescue crews had to use the Jaws of Life to remove two people from their vehicles after a wrong-way driver caused a serious accident on the Lodge Freeway.
Police say a wrong-way driver who was under the influence of alcohol crashed his full-sized van on the Lodge Freeway in Detroit.
A southeastern Michigan man has been indicted in Ohio for a wrong-way crash that killed a 26-year-old man late last year.
A 26-year-old Toledo man was killed in a head-on, wrong-way crash that also injured a Michigan man on I-75 near the state border.
Michigan State Police have released more information about the man killed Thursday in a wrong-way crash on I-96 in Detroit.
Michigan State Police say a man who was driving the wrong direction on I-96 in Detroit collided head-on with another vehicle, instantly killing the other driver.
Authorities say they arrested a 71-year-old man who reportedly drove about 13 miles into oncoming traffic on I-75 in Michigan before being stopped.