Valerie Munguia-Bryan and Mario Bryan knew for months that one of their twin babies would be born with a devastating congenital defect. But they refused to give up hope.

The couple was referred to the UM Health System by their hometown physician in Saginaw because of UM’s expertise in repairing difficult congenital defects and for heart-lung support technology known as Extracorporeal Membrane Oxygenation, or ECMO, which is used to care for desperately ill patients. Doctors expected the couple’s baby would need to be placed on ECMO to be kept alive from birth and through surgery.

ECMO was developed in the 1970s by UM surgeon Robert Bartlett, now a professor emeritus. The technology — described by some of Bartlett’s colleagues as ‘extraordinary’ — does the work of a patient’s failing heart and lungs for a period of weeks, sometimes months. That’s often long enough for the heart and lungs to rest and recover, increasing the patient’s chance of survival.

The technology has spread worldwide, with more than 40,000 cases treated and more than 24,000 lives saved. ECMO also has the extraordinary legacy of diminishing mortality in conditions where patients used to have no chance of survival.  

Manuel and Victor Bryan were born Nov. 1 at UM’s C. S. Mott Children’s Hospital.

Manuel was born healthy. But as expected, Victor’s lungs were so underdeveloped that he was placed on ECMO immediately following birth. The following day, he was taken to surgery to repair his prenatally diagnosed congenital diaphragmatic hernia — to fashion a new diaphragm and to return his stomach, liver and intestines out of the upper cavity of the chest, where they were pushing up against the heart and lungs. Infants born with a congenital diaphragmatic hernia often have respiratory problems, with the severity varying by case from mild to life-threatening.  In Victor’s case, it was life-threatening, so much so that Victor had two runs with ECMO. He is now recovering from a second surgery to close his abdomen.

“He is a fighter,” says his mom Valerie, who chose Victor’s name after her eye was caught by a University of Michigan poster invoking the school’s Hail to the Victors fight song. “He will be victorious.”

Dr. Ronald Hirschl said Victor would not be alive today were it not for ECMO technology.

“Victor had almost no diaphragm, he had small lungs, pulmonary hypertension, and blood was not going through his lungs … he needed the ECMO badly,” said Hirschl, surgeon-in-chief and section head of pediatric surgery at Mott Children’s Hospital and Victor’s surgeon.  “He is a perfect example of a child who wouldn’t be here today were it not for ECMO.

Victor has become a special baby for other reasons. He is the University of Michigan’s 2,000th patient to be placed on ECMO.

The milestone is one that was watched closely by the team of doctors, researchers, nurses and administrators who run the ECMO program.
While the numbers worldwide far exceed 2,000, UM is where the program was anchored, grew, became refined and developed into what it is today. UM is the place where thousands of doctors and nurses continue to train to bring this technology to their own hospitals. It is at UM that the most difficult cases continue to come — not only for UM’s depth of knowledge in ECMO technology and care of patients, but for life-saving programs that work in conjunction with ECMO, such as Survival Flight, which flies the sickest patients from around the country on transportable ECMO technology, and the Fetal Diagnosis and Treatment Center, which identifies problems that can be treated from prior to birth and after.

“Victor is a very special baby,” said Bartlett, who retired from clinical practice in 2005 but continues to run the large laboratory where ECMO was developed, now focused on perfecting the technology. “We can’t wait for him to join his brother Manny at home soon.”

Bartlett says the future of ECMO after this 2,000th patient milestone is brighter than ever. His lab continues to work on the development of artificial organs and surfaces to replace plastic tubing currently used to eliminate the need for blood thinners, which remains one of the biggest drawbacks of ECMO technology.

That breakthrough is just a few short years away.

Victor shares a special legacy with the first successful ECMO baby, now an adult woman whose name is Esperanza or Hope in Spanish.

Esperanza’s mom gave birth to her in California 35 years ago. In the country illegally, the frightened mom left her baby orphaned in the California hospital where Bartlett worked at the time. Her life was saved by ECMO. Esperanza was later adopted by a local family. She is now married with children, living in Missouri.

Hundreds of UM staff members have worked on the ECMO project for more than 30 years. The team has been not-so quietly cheering for Victor as he grows and overcomes hurdles. Nurses readily volunteer to hold his twin brother Manny every time Valerie visits Victor at Mott’s the Neonatal Intensive Care Unit. They will readily admit they’re in love with the infants.

While Victor still has some hurdles to overcome, Valerie and her family savor the miracle that he is alive today thanks to ECMO technology. Bartlett who is retired from practice, visits Victor periodically to check on his progress. Valerie couldn’t be happier she had a chance to thank Bartlett.

“I just wanted to make sure I could give him a hug — for saving my baby,” Valerie said.

For video on this story, visit For a slide show, visit


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