Pavel Datsyuk managed to find enough space in the tight-checking game to score with 3:01 left and give the Red Wings a 1-0 win on Friday night.
Boston is the NHL’s best team, albeit one Detroit has defeated in three of four meetings this season.
The Boston Bruins won the Presidents’ Trophy by leading the NHL with 117 points.
The Boston Bruins had the NHL’s best record, allowed the second fewest goals and scored the third most.
The Detroit Red Wings beat the odds and made the playoffs for a 23rd straight season, and now comes the hard part.
Nyquist broke a tie with 7:12 left in the third period on his only shot of the game, and the Detroit Red Wings held on to beat Boston 3-2 on Wednesday night.
Zetterberg joins a list of injured Red Wings which includes their leading goal-scorer, forward Pavel Datsyuk, who suffered a concussion on Nov. 23 against the Ottawa Senators.
The Detroit Red Wings used a balanced offense to take care of the Boston Bruins.
Gustavsson didn’t find out until nearly game time that Detroit’s No. 1 goaltender Jimmy Howard was going to be sidelined with a catching hand injury.
Stephen Weiss and Daniel Cleary scored second-period goals, reserve goaltender Jonas Gustavsson made 28 saves in his first action of the season and the Detroit Red Wings edged the Boston Bruins 3-2 Monday.